The membrane attack complex (MAC) is formed by which complement components?

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Study for the Manor Preboards Module 2 Test. Use flashcards and multiple choice questions that include hints and explanations. Prepare thoroughly for your exam!

Multiple Choice

The membrane attack complex (MAC) is formed by which complement components?

Explanation:
The membrane attack complex is formed by the terminal assembly of the complement cascade, where C5b binds sequentially to C6, C7, C8, and multiple C9 molecules to create the C5b-9 complex. This pore disrupts the target cell membrane, causing lysis. Other components have different roles: C3b serves as an opsonin, C4a and C3a act as inflammatory mediators, and C1q initiates the classical pathway. So the MAC is the C5b-9 complex.

The membrane attack complex is formed by the terminal assembly of the complement cascade, where C5b binds sequentially to C6, C7, C8, and multiple C9 molecules to create the C5b-9 complex. This pore disrupts the target cell membrane, causing lysis. Other components have different roles: C3b serves as an opsonin, C4a and C3a act as inflammatory mediators, and C1q initiates the classical pathway. So the MAC is the C5b-9 complex.

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